Ontology highlight
ABSTRACT:
SUBMITTER: Seney ML
PROVIDER: S-EPMC6689017 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Seney Marianne L ML Cahill Kelly K Enwright John F JF Logan Ryan W RW Huo Zhiguang Z Zong Wei W Tseng George G McClung Colleen A CA
Nature communications 20190809 1
Schizophrenia is associated with disrupted cognitive control and sleep-wake cycles. Here we identify diurnal rhythms in gene expression in the human dorsolateral prefrontal cortex (dlPFC), in schizophrenia and control subjects. We find significant diurnal (24 h) rhythms in control subjects, however, most of these transcripts are not rhythmic in subjects with schizophrenia. Instead, subjects with schizophrenia have a different set of rhythmic transcripts. The top pathways identified in transcript ...[more]