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Endo- and Exo-Functionalized Tetraphenylethylene M12L24 Nanospheres: Fluorescence Emission inside a Confined Space.


ABSTRACT: The intrinsic relationship between the properties of green fluorescent protein (GFP) and its encapsulated small molecular light machine has spurred many biomimicking studies, aiming at revealing the detailed mechanism and further promoting its wide applications in different disciplines. However, how to build a similar confined microenvironment to mimic the cavity of a ?-barrel and the fluorescence turn-on process is a fundamental challenge for both chemists and biologists. Herein, two distinct exo- and endo-functionalized tetraphenylethylene (TPE)-based M12L24 nanospheres with precise distribution of anchored TPE moieties and unique photophysical properties were constructed by means of a coordination-driven self-assembly strategy. Under dilute conditions, the nanospheres fluoresce more strongly than the corresponding TPE subcomponents. Meanwhile, the endo-functionalized sphere is able to induce a higher local concentration and more restrained motion of the enclosed 24 TPE units compared with exo-functionalized counterpart and thus induces much stronger emission due to the restriction of the rotation of the pendant TPE units. The biomimetic methodology developed here represents a promising way to understand and construct artificial GFP materials on the platforms of supramolecular coordination complexes.

SUBMITTER: Yan X 

PROVIDER: S-EPMC6689230 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Endo- and Exo-Functionalized Tetraphenylethylene M<sub>12</sub>L<sub>24</sub> Nanospheres: Fluorescence Emission inside a Confined Space.

Yan Xuzhou X   Wei Peifa P   Liu Yuhang Y   Wang Ming M   Chen Chuanshuang C   Zhao Jun J   Li Guangfeng G   Saha Manik Lal ML   Zhou Zhixuan Z   An Zhe Z   Li Xiaopeng X   Stang Peter J PJ  

Journal of the American Chemical Society 20190607 24


The intrinsic relationship between the properties of green fluorescent protein (GFP) and its encapsulated small molecular light machine has spurred many biomimicking studies, aiming at revealing the detailed mechanism and further promoting its wide applications in different disciplines. However, how to build a similar confined microenvironment to mimic the cavity of a β-barrel and the fluorescence turn-on process is a fundamental challenge for both chemists and biologists. Herein, two distinct e  ...[more]

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