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Delayed childhood neurodevelopment and neurosensory alterations in the second year of life in a prospective cohort of ZIKV-exposed children.

ABSTRACT: We report neurodevelopmental outcomes in 216 infants followed since the time of PCR-confirmed maternal Zika virus (ZIKV) infection in pregnancy during the Rio de Janeiro epidemic of 2015-2016 (refs. 1,2). Neurodevelopment was assessed by Bayley Scales of Infant and Toddler Development, third edition (Bayley-III; cognitive, language and motor domains) in 146?children and through neurodevelopment questionnaires/neurological examinations in 70?remaining children. Complete eye exams (n?=?137) and hearing assessments (n?=?114) were also performed. Below-average neurodevelopment and/or abnormal eye or hearing assessments were noted in 31.5% of children between 7 and 32?months of age. Among children assessed by Bayley-III, 12% scored below -2?s.d. (score?<70; a score of 100?±?2?s.d. is the range) in at least one domain; and 28% scored between -1 and -2?s.d. in any domain (scores?<85-70). Language function was most affected, with 35% of 146?children below average. Improved neurodevelopmental outcomes were noted in female children, term babies, children with normal eye exams and maternal infection later in pregnancy (P?=?0.01). We noted resolution of microcephaly with normal neurodevelopment in two of eight children, development of secondary microcephaly in two other children and autism spectrum disorder in three previously healthy children in the second year of life.

SUBMITTER: Nielsen-Saines K

PROVIDER: S-EPMC6689256 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Delayed childhood neurodevelopment and neurosensory alterations in the second year of life in a prospective cohort of ZIKV-exposed children.

Nielsen-Saines Karin K Brasil Patrícia P Kerin Tara T Vasconcelos Zilton Z Gabaglia Claudia Raja CR Damasceno Luana L Pone Marcos M Abreu de Carvalho Liege M LM Pone Sheila M SM Zin Andrea A AA Tsui Irena I Salles Tania Regina S TRS da Cunha Denise Cotrim DC Costa Roozemerie Pereira RP Malacarne Jociele J Reis Ana Beatriz AB Hasue Renata Hydee RH Aizawa Carolina Y P CYP Genovesi Fernanda F FF Einspieler Christa C Marschik Peter B PB Pereira José Paulo JP Gaw Stephanie L SL Adachi Kristina K Cherry James D JD Xu Zhiheng Z Cheng Genhong G Moreira Maria Elisabeth ME

Nature medicine 20190708 8

We report neurodevelopmental outcomes in 216 infants followed since the time of PCR-confirmed maternal Zika virus (ZIKV) infection in pregnancy during the Rio de Janeiro epidemic of 2015-2016 (refs. <sup>1,2</sup>). Neurodevelopment was assessed by Bayley Scales of Infant and Toddler Development, third edition (Bayley-III; cognitive, language and motor domains) in 146 children and through neurodevelopment questionnaires/neurological examinations in 70 remaining children. Complete eye exams (n = ...[more]

PMID: 31285631

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Dataset Information

Delayed childhood neurodevelopment and neurosensory alterations in the second year of life in a prospective cohort of ZIKV-exposed children.

Publications

Delayed childhood neurodevelopment and neurosensory alterations in the second year of life in a prospective cohort of ZIKV-exposed children.

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