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Pulsed Excitation in Magnetic Particle Imaging.


ABSTRACT: Magnetic particle imaging (MPI) is a promising new tracer-based imaging modality. The steady-state, nonlinear magnetization physics most fundamental to MPI typically predicts improving resolution with increasing tracer magnetic core size. For larger tracers, and given typical excitation slew rates, this steady-state prediction is compromised by dynamic processes that induce a significant secondary blur and prevent us from achieving high resolution using larger tracers. Here, we propose a new method of excitation and signal encoding in MPI we call pulsed MPI to overcome this phenomenon. Pulsed MPI allows us to directly encode the steady-state magnetic physics into the time-domain signal. This in turn gives rise to a simple reconstruction algorithm to obtain images free of secondary relaxation-induced blur. Here, we provide a detailed description of our approach in 1D, discuss how it compares with alternative approaches, and show experimental data demonstrating better than 500- [Formula: see text] resolution (at 7 T/m) with large tracers. Finally, we show experimental images from a 2D implementation.

SUBMITTER: Tay ZW 

PROVIDER: S-EPMC6689437 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Pulsed Excitation in Magnetic Particle Imaging.

Tay Zhi Wei ZW   Hensley Daniel D   Ma Jie J   Chandrasekharan Prashant P   Zheng Bo B   Goodwill Patrick P   Conolly Steven S  

IEEE transactions on medical imaging 20190211 10


Magnetic particle imaging (MPI) is a promising new tracer-based imaging modality. The steady-state, nonlinear magnetization physics most fundamental to MPI typically predicts improving resolution with increasing tracer magnetic core size. For larger tracers, and given typical excitation slew rates, this steady-state prediction is compromised by dynamic processes that induce a significant secondary blur and prevent us from achieving high resolution using larger tracers. Here, we propose a new met  ...[more]

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