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White matter development in infants at risk for schizophrenia.


ABSTRACT: BACKGROUND:Schizophrenia is considered a neurodevelopmental disorder with a pathophysiology that likely begins long before the onset of clinical symptoms. White matter abnormalities have been observed in schizophrenia and we hypothesized that the first 2?years of life is a period in which white matter abnormalities associated with schizophrenia risk may emerge. METHODS:38 infants at high risk for schizophrenia and 202 healthy controls underwent diffusion tensor MRIs after birth and at 1 and 2?years of age. Quantitative tractography was used to determine diffusion properties (fractional anisotropy (FA), axial diffusivity (AD), and radial diffusivity (RD)) of 18 white matter tracts and a general linear model was used to analyze group differences at each age. RESULTS:Adjusting gestational age at birth, postnatal age at MRI, gender, MRI scanner type, and maternal education, neonates at high risk had significantly lower FA (p?=?0.02) and AD (p?=?0.03) in the superior segment of the left cingulate, and higher RD in the hippocampal segment of the left cingulate (p?=?0.04). High risk one year olds had significantly lower FA (p?

SUBMITTER: Ahn SJ 

PROVIDER: S-EPMC6689450 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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White matter development in infants at risk for schizophrenia.

Ahn Sung Jun SJ   Cornea Emil E   Murphy Veronica V   Styner Martin M   Jarskog L Fredrik LF   Gilmore John H JH  

Schizophrenia research 20190608


<h4>Background</h4>Schizophrenia is considered a neurodevelopmental disorder with a pathophysiology that likely begins long before the onset of clinical symptoms. White matter abnormalities have been observed in schizophrenia and we hypothesized that the first 2 years of life is a period in which white matter abnormalities associated with schizophrenia risk may emerge.<h4>Methods</h4>38 infants at high risk for schizophrenia and 202 healthy controls underwent diffusion tensor MRIs after birth an  ...[more]

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