Ontology highlight
ABSTRACT:
SUBMITTER: Galli E
PROVIDER: S-EPMC6689469 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Galli Edoardo E Hartmann Felix J FJ Schreiner Bettina B Ingelfinger Florian F Arvaniti Eirini E Diebold Martin M Mrdjen Dunja D van der Meer Franziska F Krieg Carsten C Nimer Faiez Al FA Sanderson Nicholas N Stadelmann Christine C Khademi Mohsen M Piehl Fredrik F Claassen Manfred M Derfuss Tobias T Olsson Tomas T Becher Burkhard B
Nature medicine 20190722 8
Cytokine dysregulation is a central driver of chronic inflammatory diseases such as multiple sclerosis (MS). Here, we sought to determine the characteristic cellular and cytokine polarization profile in patients with relapsing-remitting multiple sclerosis (RRMS) by high-dimensional single-cell mass cytometry (CyTOF). Using a combination of neural network-based representation learning algorithms, we identified an expanded T helper cell subset in patients with MS, characterized by the expression o ...[more]