Ontology highlight
ABSTRACT:
SUBMITTER: Bockwoldt M
PROVIDER: S-EPMC6689970 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Bockwoldt Mathias M Houry Dorothée D Niere Marc M Gossmann Toni I TI Reinartz Ines I Schug Alexander A Ziegler Mathias M Heiland Ines I
Proceedings of the National Academy of Sciences of the United States of America 20190724 32
Nicotinamide adenine dinucleotide (NAD) provides an important link between metabolism and signal transduction and has emerged as central hub between bioenergetics and all major cellular events. NAD-dependent signaling (e.g., by sirtuins and poly-adenosine diphosphate [ADP] ribose polymerases [PARPs]) consumes considerable amounts of NAD. To maintain physiological functions, NAD consumption and biosynthesis need to be carefully balanced. Using extensive phylogenetic analyses, mathematical modelin ...[more]