Ontology highlight
ABSTRACT:
SUBMITTER: Beaudoin JD
PROVIDER: S-EPMC6690192 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Beaudoin Jean-Denis JD Novoa Eva Maria EM Vejnar Charles E CE Yartseva Valeria V Takacs Carter M CM Kellis Manolis M Giraldez Antonio J AJ
Nature structural & molecular biology 20180730 8
RNA folding plays a crucial role in RNA function. However, knowledge of the global structure of the transcriptome is limited to cellular systems at steady state, thus hindering the understanding of RNA structure dynamics during biological transitions and how it influences gene function. Here, we characterized mRNA structure dynamics during zebrafish development. We observed that on a global level, translation guides structure rather than structure guiding translation. We detected a decrease in s ...[more]