Ontology highlight
ABSTRACT:
SUBMITTER: Ozen A
PROVIDER: S-EPMC6690356 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Ozen Ahmet A Comrie William A WA Ardy Rico C RC Domínguez Conde Cecilia C Dalgic Buket B Beser Ömer F ÖF Morawski Aaron R AR Karakoc-Aydiner Elif E Tutar Engin E Baris Safa S Ozcay Figen F Serwas Nina K NK Zhang Yu Y Matthews Helen F HF Pittaluga Stefania S Folio Les R LR Unlusoy Aksu Aysel A McElwee Joshua J JJ Krolo Ana A Kiykim Ayca A Baris Zeren Z Gulsan Meltem M Ogulur Ismail I Snapper Scott B SB Houwen Roderick H J RHJ Leavis Helen L HL Ertem Deniz D Kain Renate R Sari Sinan S Erkan Tülay T Su Helen C HC Boztug Kaan K Lenardo Michael J MJ
The New England journal of medicine 20170628 1
<h4>Background</h4>Studies of monogenic gastrointestinal diseases have revealed molecular pathways critical to gut homeostasis and enabled the development of targeted therapies.<h4>Methods</h4>We studied 11 patients with abdominal pain and diarrhea caused by early-onset protein-losing enteropathy with primary intestinal lymphangiectasia, edema due to hypoproteinemia, malabsorption, and less frequently, bowel inflammation, recurrent infections, and angiopathic thromboembolic disease; the disorder ...[more]