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Nickel-catalyzed, ring-forming aromatic C-H alkylations with unactivated alkyl halides.

ABSTRACT: The development of a nickel-catalyzed C-H alkylation of aromatic substrates with unactivated alkyl halides is described. This carbocyclization facilitates the synthesis of diverse fused ring systems from simple aromatic substrates and is an attractive alternative to traditional polar or radical-mediated ring formations. The present system uses unactivated primary and secondary alkyl bromides and chlorides, while avoiding the use of precious palladium catalysts and more reactive alkyl halides commonly used in related C-H alkylations.

SUBMITTER: Tercenio QD

PROVIDER: S-EPMC6690380 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Nickel-catalyzed, ring-forming aromatic C-H alkylations with unactivated alkyl halides.

Tercenio Quentin D QD Alexanian Erik J EJ

Tetrahedron 20190525 31

The development of a nickel-catalyzed C-H alkylation of aromatic substrates with unactivated alkyl halides is described. This carbocyclization facilitates the synthesis of diverse fused ring systems from simple aromatic substrates and is an attractive alternative to traditional polar or radical-mediated ring formations. The present system uses unactivated primary and secondary alkyl bromides and chlorides, while avoiding the use of precious palladium catalysts and more reactive alkyl halides com ...[more]

PMID: 31406389

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