A vicious cycle of ? amyloid-dependent neuronal hyperactivation.
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ABSTRACT:
SUBMITTER: Zott B
PROVIDER: S-EPMC6690382 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Publications
A vicious cycle of β amyloid-dependent neuronal hyperactivation.
Zott Benedikt B Simon Manuel M MM Hong Wei W Unger Felix F Chen-Engerer Hsing-Jung HJ Frosch Matthew P MP Sakmann Bert B Walsh Dominic M DM Konnerth Arthur A
Science (New York, N.Y.) 20190801 6453
β-amyloid (Aβ)-dependent neuronal hyperactivity is believed to contribute to the circuit dysfunction that characterizes the early stages of Alzheimer's disease (AD). Although experimental evidence in support of this hypothesis continues to accrue, the underlying pathological mechanisms are not well understood. In this experiment, we used mouse models of Aβ-amyloidosis to show that hyperactivation is initiated by the suppression of glutamate reuptake. Hyperactivity occurred in neurons with preexi ...[more]
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