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Assessment of Disease Activity in Large-vessel Vasculitis: Results of an International Delphi Exercise.

ABSTRACT: OBJECTIVE:To arrive at consensus for candidate outcomes for disease activity assessment in large-vessel vasculitis (LVV) in clinical trials. METHODS:A Delphi survey including 99 items was circulated among international experts for 3 rounds. RESULTS:Fifty-seven items were accepted for both giant cell arteritis and Takayasu arteritis. Sixty-seven percent of experts voted to have a common approach for both diseases with additional disease-specific items such as weight loss, scalp tenderness/necrosis, morning stiffness, dizziness, visual symptoms, and imaging. CONCLUSION:This study highlights similarities and differences in experts' perspectives for assessing clinical activity in LVV and may guide a consensus-driven core set of validated outcomes.

SUBMITTER: Aydin SZ

PROVIDER: S-EPMC6690481 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Assessment of Disease Activity in Large-vessel Vasculitis: Results of an International Delphi Exercise.

Aydin Sibel Z SZ Direskeneli Haner H Merkel Peter A PA

The Journal of rheumatology 20170901 12

<h4>Objective</h4>To arrive at consensus for candidate outcomes for disease activity assessment in large-vessel vasculitis (LVV) in clinical trials.<h4>Methods</h4>A Delphi survey including 99 items was circulated among international experts for 3 rounds.<h4>Results</h4>Fifty-seven items were accepted for both giant cell arteritis and Takayasu arteritis. Sixty-seven percent of experts voted to have a common approach for both diseases with additional disease-specific items such as weight loss, sc ...[more]

PMID: 28864648

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