High-throughput 16S rRNA gene sequencing reveals that 6-hydroxydopamine affects gut microbial environment.
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ABSTRACT:
SUBMITTER: Choi JG
PROVIDER: S-EPMC6690581 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
High-throughput 16S rRNA gene sequencing reveals that 6-hydroxydopamine affects gut microbial environment.
Choi Jin Gyu JG Huh Eugene E Kim Namkwon N Kim Dong-Hyun DH Oh Myung Sook MS
PloS one 20190812 8
Recently, there has been a rapid increase in studies on the relationship between brain diseases and gut microbiota, and clinical evidence on gut microbial changes in Parkinson's disease (PD) has accumulated. 6-Hydroxydopamine (6-OHDA) is a widely used neurotoxin that leads to PD pathogenesis, but whether 6-OHDA affects gut microbial environment has not been investigated. Here we performed the 16S rRNA gene sequencing to analyze the gut microbial community of mice. We found that there were no sig ...[more]
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