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Sofosbuvir Add-on to Ribavirin Treatment for Chronic Hepatitis E Virus Infection in Solid Organ Transplant Recipients Does Not Result in Sustained Virological Response.

ABSTRACT: Ribavirin is effective for treating immunocompromised patients with chronic hepatitis E virus infection. However, ribavirin treatment is not always successful. We describe 3 solid organ transplant recipients treated with sofosbuvir and ribavirin after failing ribavirin monotherapy. Complete elimination of hepatitis E virus could not be achieved.

SUBMITTER: van Wezel EM 

PROVIDER: S-EPMC6690733 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Sofosbuvir Add-on to Ribavirin Treatment for Chronic Hepatitis E Virus Infection in Solid Organ Transplant Recipients Does Not Result in Sustained Virological Response.

van Wezel E M EM   de Bruijne J J   Damman K K   Bijmolen M M   van den Berg A P AP   Verschuuren E A M EAM   Ruigrok G A GA   Riezebos-Brilman A A   Knoester M M  

Open forum infectious diseases 20190801 8

Ribavirin is effective for treating immunocompromised patients with chronic hepatitis E virus infection. However, ribavirin treatment is not always successful. We describe 3 solid organ transplant recipients treated with sofosbuvir and ribavirin after failing ribavirin monotherapy. Complete elimination of hepatitis E virus could not be achieved. ...[more]

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