Ontology highlight
ABSTRACT:
SUBMITTER: Chang YT
PROVIDER: S-EPMC6690972 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Chang Ying-Tzu YT Teng Yu-Ning YN Lin Kun-I KI Wang Charles C N CCN Morris-Natschke Susan L SL Lee Kuo-Hsiung KH Hung Chin-Chuan CC
Scientific reports 20190812 1
Multidrug resistance presents an obstacle in cancer treatment. Among numerous combative strategies, collateral sensitivity (CS) drugs have opened a new avenue to defeat cancer by exploiting selective toxicity against multidrug-resistant (MDR) cancer. In the present study, a clinically used synthetic steroid hormone, danazol, was investigated for its CS properties and cytotoxic mechanisms. Compared with natural hormones, danazol possessed a stronger selective cytotoxicity against MDR cancer cells ...[more]