Ontology highlight
ABSTRACT:
SUBMITTER: Ghiringhelli F
PROVIDER: S-EPMC6691024 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Ghiringhelli François F Fumet Jean-David JD
Frontiers in immunology 20190806
Immunotherapy using checkpoint inhibitor targeting PD-1 and PD-L1 revolutionized the treatment of microsatellite instable metastatic colon cancer. Such treatment is now a standard of care for these patients. However, when used as monotherapy checkpoint inhibitors targeting PD-1 and PD-L1 are not effective in metastatic colorectal cancer patients with microsatellite stable tumors. Recent advances in biology provide a rationale for this intrinsic resistance and support the evaluation of combinatio ...[more]