Trastuzumab gold-conjugates: synthetic approach and in vitro evaluation of anticancer activities in breast cancer cell lines.
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ABSTRACT:
SUBMITTER: Curado N
PROVIDER: S-EPMC6691192 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Publications
Trastuzumab gold-conjugates: synthetic approach and in vitro evaluation of anticancer activities in breast cancer cell lines.
Curado Natalia N Dewaele-Le Roi Guillaume G Poty Sophie S Lewis Jason S JS Contel Maria M
Chemical communications (Cambridge, England) 20190101 10
We describe the preparation of gold(i)-compounds that are amenable to efficient bioconjugation with monoclonal antibodies via activated ester or maleimide linkers. New Trastuzumab-gold conjugates were synthesized and fully characterized. These bioconjugates are significantly more cytotoxic (sub-micromolar range) to HER2-positive breast cancer cells than the gold complexes and Trastuzumab. ...[more]
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