Ontology highlight
ABSTRACT:
SUBMITTER: Zheng L
PROVIDER: S-EPMC6691507 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Zheng Li L Nagar Mitesh M Maurais Aaron J AJ Slade Daniel J DJ Parelkar Sangram S SS Coonrod Scott A SA Weerapana Eranthie E Thompson Paul R PR
Biochemistry 20190627 27
Protein arginine deiminases (PADs) are calcium-dependent enzymes that mediate the post-translational conversion of arginine into citrulline. Dysregulated PAD activity is associated with numerous autoimmune disorders and cancers. In breast cancer, PAD2 citrullinates histone H3R26 and activates the transcription of estrogen receptor target genes. However, PAD2 lacks a canonical nuclear localization sequence, and it is unclear how this enzyme is transported into the nucleus. Here, we show for the f ...[more]