Ontology highlight
ABSTRACT:
SUBMITTER: Su CM
PROVIDER: S-EPMC6691761 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Journal of enzyme inhibition and medicinal chemistry 20191201 1
Inhibition of NF-κB signalling has been demonstrated as a therapeutic option in treating inflammatory diseases and cancers. Herein, we synthesized novel dissymmetric 3,5-bis(arylidene)-4-piperidones (BAPs, <b>83-102</b>) and characterized fully. MTT and ELISA assay were performed to screen the anti-hepatoma and anti-inflammation properties. <b>96</b> showed the most potential bioactivity. <b>96</b> could promote HepG2 apoptosis through up-regulating the expression of C-Caspase-3 and Bax, down-re ...[more]