Ontology highlight
ABSTRACT:
SUBMITTER: Elmeligie S
PROVIDER: S-EPMC6691788 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Elmeligie Salwa S Aboul-Magd Asmaa M AM Lasheen Deena S DS Ibrahim Tamer M TM Abdelghany Tamer M TM Khojah Sohair M SM Abouzid Khaled A M KAM
Journal of enzyme inhibition and medicinal chemistry 20191201 1
In the designed compounds, either a biarylamide or biarylurea moiety or an N-substituted piperazine motif was linked to position 1 of the phthalazine core. The anti-proliferative activity of the synthesised compounds revealed that eight compounds (<b>6b, 6e, 7b, 13a, 13c, 16a, 16d and 17a</b>) exhibited excellent broad spectrum cytotoxic activity in NCI 5-log dose assays against the full 60 cell panel with GI<sub>50</sub> values ranging from 0.15 to 8.41 µM. Moreover, the enzymatic assessment of ...[more]