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Efomycins K and L From a Termite-Associated Streptomyces sp. M56 and Their Putative Biosynthetic Origin.


ABSTRACT: Two new elaiophylin derivatives, efomycins K (1) and L (2), and five known elaiophylin derivatives (3-7) were isolated from the termite-associated Streptomyces sp. M56. The structures were determined by 1D and 2D NMR and HR-ESIMS analyses and comparative CD spectroscopy. The putative gene cluster responsible for the production of the elaiophylin and efomycin derivatives was identified based on significant homology to related clusters. Phylogenetic analysis of gene cluster domains was used to provide a biosynthetic rational for these new derivatives and to demonstrate how a single biosynthetic pathway can produce diverse structures.

SUBMITTER: Klassen JL 

PROVIDER: S-EPMC6691879 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Efomycins K and L From a Termite-Associated <i>Streptomyces</i> sp. M56 and Their Putative Biosynthetic Origin.

Klassen Jonathan L JL   Lee Seoung Rak SR   Poulsen Michael M   Beemelmanns Christine C   Kim Ki Hyun KH  

Frontiers in microbiology 20190806


Two new elaiophylin derivatives, efomycins K (<b>1</b>) and L (<b>2</b>), and five known elaiophylin derivatives (<b>3-7</b>) were isolated from the termite-associated <i>Streptomyces</i> sp. M56. The structures were determined by 1D and 2D NMR and HR-ESIMS analyses and comparative CD spectroscopy. The putative gene cluster responsible for the production of the elaiophylin and efomycin derivatives was identified based on significant homology to related clusters. Phylogenetic analysis of gene clu  ...[more]

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