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Epigenome-wide effects of vitamin D on asthma bronchial epithelial cells.

ABSTRACT: Vitamin D is a nutrient and a hormone with multiple effects on immune regulation and respiratory viral infections, which can worsen asthma and lead to severe asthma exacerbations. We set up a complete experimental and analytical pipeline for ATAC-Seq and RNA-Seq to study genome-wide epigenetic changes in human bronchial epithelial cells of asthmatic subjects, following treatment of these cells with calcitriol (vitamin D3) and Poly (I:C)(a viral analogue). This approach led to the identification of biologically plausible candidate genes for viral infections and asthma, such as DUSP10 and SLC44A1.

SUBMITTER: Boutaoui N 

PROVIDER: S-EPMC6691985 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Epigenome-wide effects of vitamin D on asthma bronchial epithelial cells.

Boutaoui Nadia N   Puranik Sandeep S   Zhang Rong R   Wang Ting T   Hui Daniel H DH   Brehm John J   Forno Erick E   Chen Wei W   Celedón Juan C JC  

Epigenetics 20190603 9

Vitamin D is a nutrient and a hormone with multiple effects on immune regulation and respiratory viral infections, which can worsen asthma and lead to severe asthma exacerbations. We set up a complete experimental and analytical pipeline for ATAC-Seq and RNA-Seq to study genome-wide epigenetic changes in human bronchial epithelial cells of asthmatic subjects, following treatment of these cells with calcitriol (vitamin D3) and Poly (I:C)(a viral analogue). This approach led to the identification  ...[more]

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