Combination antioxidant therapy prevents epileptogenesis and modifies chronic epilepsy.
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ABSTRACT:
SUBMITTER: Shekh-Ahmad T
PROVIDER: S-EPMC6692059 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
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Combination antioxidant therapy prevents epileptogenesis and modifies chronic epilepsy.
Shekh-Ahmad Tawfeeq T Lieb Andreas A Kovac Stjepana S Gola Lukas L Christian Wigley W W Abramov Andrey Y AY Walker Matthew C MC
Redox biology 20190719
Many epilepsies are acquired conditions following an insult to the brain such as a prolonged seizure, traumatic brain injury or stroke. The generation of reactive oxygen species (ROS) and induction of oxidative stress are common sequelae of such brain insults and have been shown to contribute to neuronal death and the development of epilepsy. Here, we show that combination therapy targeting the generation of ROS through NADPH oxidase inhibition and the endogenous antioxidant system through nucle ...[more]
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