Ontology highlight
ABSTRACT:
SUBMITTER: Prasad B
PROVIDER: S-EPMC6692196 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Prasad Bhagwat B Achour Brahim B Artursson Per P Hop Cornelis E C A CECA Lai Yurong Y Smith Philip C PC Barber Jill J Wisniewski Jacek R JR Spellman Daniel D Uchida Yasuo Y Zientek Michael A MA Unadkat Jashvant D JD Rostami-Hodjegan Amin A
Clinical pharmacology and therapeutics 20190726 3
Quantitative translation of information on drug absorption, disposition, receptor engagement, and drug-drug interactions from bench to bedside requires models informed by physiological parameters that link in vitro studies to in vivo outcomes. To predict in vivo outcomes, biochemical data from experimental systems are routinely scaled using protein quantity in these systems and relevant tissues. Although several laboratories have generated useful quantitative proteomic data using state-of-the-ar ...[more]