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Benefit of Adjuvant Chemoradiotherapy in Resected Gallbladder Carcinoma.


ABSTRACT: To evaluate the benefit of adjuvant treatments, such as chemoradiotherapy (CRT) and chemotherapy (CTx), compared with no adjuvant treatment (No-AT) in resected gallbladder (GB) cancer patients, 151 patients were analyzed: 98 (64.9%) patients received adjuvant treatment with CRT (n?=?59, 39.1%) or CTx (n?=?39, 25.8%), and the remaining 53 (35.1%) did not (No-AT). The clinicopathological factors, patterns of failure, locoregional recurrence-free survival (LRFS), recurrence-free survival (RFS) and overall survival (OS) were compared among the three groups according to tumor stage. In patients with T2-3N0M0 stage disease, the incidences of locoregional recurrence and distant recurrence and 5-year LRFS, RFS and OS rates were not significantly different among the No-AT, CTx, and CRT groups (p?>?0.05 each). In those with T2-3N1-2M0 stage disease, the incidences of locoregional recurrence (11.4%, 78.1%, and 68.4%, respectively) and distant recurrence (42.8%, 73.9% and 66.7%, respectively) in the CRT group were significantly lower than those in the No-AT and CTx groups (p?

SUBMITTER: Kim TH 

PROVIDER: S-EPMC6692378 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Benefit of Adjuvant Chemoradiotherapy in Resected Gallbladder Carcinoma.

Kim Tae Hyun TH   Woo Sang Myung SM   Lee Woo Jin WJ   Oh Eun Sang ES   Youn Sang Hee SH   Moon Sung Ho SH   Kim Sang Soo SS   Han Sung Sik SS   Park Sang-Jae SJ   Kim Dae Yong DY  

Scientific reports 20190813 1


To evaluate the benefit of adjuvant treatments, such as chemoradiotherapy (CRT) and chemotherapy (CTx), compared with no adjuvant treatment (No-AT) in resected gallbladder (GB) cancer patients, 151 patients were analyzed: 98 (64.9%) patients received adjuvant treatment with CRT (n = 59, 39.1%) or CTx (n = 39, 25.8%), and the remaining 53 (35.1%) did not (No-AT). The clinicopathological factors, patterns of failure, locoregional recurrence-free survival (LRFS), recurrence-free survival (RFS) and  ...[more]

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