Unknown

Dataset Information

0

Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes.

ABSTRACT: Excessive daytime sleepiness (EDS) affects 10-20% of the population and is associated with substantial functional deficits. Here, we identify 42 loci for self-reported daytime sleepiness in GWAS of 452,071 individuals from the UK Biobank, with enrichment for genes expressed in brain tissues and in neuronal transmission pathways. We confirm the aggregate effect of a genetic risk score of 42 SNPs on daytime sleepiness in independent Scandinavian cohorts and on other sleep disorders (restless legs syndrome, insomnia) and sleep traits (duration, chronotype, accelerometer-derived sleep efficiency and daytime naps or inactivity). However, individual daytime sleepiness signals vary in their associations with objective short vs long sleep, and with markers of sleep continuity. The 42 sleepiness variants primarily cluster into two predominant composite biological subtypes - sleep propensity and sleep fragmentation. Shared genetic links are also seen with obesity, coronary heart disease, psychiatric diseases, cognitive traits and reproductive ageing.

SUBMITTER: Wang H 

PROVIDER: S-EPMC6692391 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes.

Wang Heming H   Lane Jacqueline M JM   Jones Samuel E SE   Dashti Hassan S HS   Ollila Hanna M HM   Wood Andrew R AR   van Hees Vincent T VT   Brumpton Ben B   Winsvold Bendik S BS   Kantojärvi Katri K   Palviainen Teemu T   Cade Brian E BE   Sofer Tamar T   Song Yanwei Y   Patel Krunal K   Anderson Simon G SG   Bechtold David A DA   Bowden Jack J   Emsley Richard R   Kyle Simon D SD   Little Max A MA   Loudon Andrew S AS   Scheer Frank A J L FAJL   Purcell Shaun M SM   Richmond Rebecca C RC   Spiegelhalder Kai K   Tyrrell Jessica J   Zhu Xiaofeng X   Hublin Christer C   Kaprio Jaakko A JA   Kristiansson Kati K   Sulkava Sonja S   Paunio Tiina T   Hveem Kristian K   Nielsen Jonas B JB   Willer Cristen J CJ   Zwart John-Anker JA   Strand Linn B LB   Frayling Timothy M TM   Ray David D   Lawlor Deborah A DA   Rutter Martin K MK   Weedon Michael N MN   Redline Susan S   Saxena Richa R  

Nature communications 20190813 1

Excessive daytime sleepiness (EDS) affects 10-20% of the population and is associated with substantial functional deficits. Here, we identify 42 loci for self-reported daytime sleepiness in GWAS of 452,071 individuals from the UK Biobank, with enrichment for genes expressed in brain tissues and in neuronal transmission pathways. We confirm the aggregate effect of a genetic risk score of 42 SNPs on daytime sleepiness in independent Scandinavian cohorts and on other sleep disorders (restless legs  ...[more]

Similar Datasets

Unknown Self-reported body silhouette trajectories across the lifespan and excessive daytime sleepiness in adulthood: a retrospective analysis. The Paris Prospective Study III.
| S-EPMC5875603 | biostudies-literature
Unknown Impaired Patient-Reported Outcomes Predict Poor School Functioning and Daytime Sleepiness: The PROMIS Pediatric Asthma Study.
| S-EPMC5673502 | biostudies-literature
Unknown An Ultra-Short Measure of Excessive Daytime Sleepiness Is Related to Circadian Biological Rhythms: The French Psychometric Validation of the Barcelona Sleepiness Index.
| S-EPMC9267909 | biostudies-literature
Unknown Daytime sleepiness in Parkinson's disease: a reappraisal.
| S-EPMC4157859 | biostudies-other
Unknown Physiological correlates of the Epworth Sleepiness Scale reveal different dimensions of daytime sleepiness.
| S-EPMC8266524 | biostudies-literature
Unknown GWAS Identifies 44 Independent Associated Genomic Loci for Self-Reported Adult Hearing Difficulty in UK Biobank.
| S-EPMC6817556 | biostudies-literature
Unknown Joint effects of OSA and self-reported sleepiness on incident CHD and stroke.
| S-EPMC5854212 | biostudies-literature
Unknown A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
| S-EPMC3753407 | biostudies-literature
Unknown Symptoms of Daytime Sleepiness and Sleep Apnea among Pregnant Women.
| S-EPMC7306166 | biostudies-literature
Unknown Longitudinal assessment of excessive daytime sleepiness in early Parkinson's disease.
| S-EPMC7282477 | biostudies-literature