Ontology highlight
ABSTRACT:
SUBMITTER: Cui L
PROVIDER: S-EPMC6692485 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Cui Liang L Zheng Weinan W Li Minghui M Bai Xiaoyuan X Yang Wenxian W Li Jing J Fan Wenhui W Gao George Fu GF Sun Lei L Liu Wenjun W
Frontiers in microbiology 20190807
Phosphorylation and dephosphorylation of nucleoprotein (NP) play significant roles in the life cycle of influenza A virus (IAV), and the biological functions of each phosphorylation site on NP are not exactly the same in controlling viral replication. Here, we identified tyrosine 78 residue (Y78) of NP as a novel phosphorylation site by mass spectrometry. Y78 is highly conserved, and the constant NP phosphorylation mimicked by Y78E delayed NP nuclear export through reducing the binding of NP to ...[more]