Dataset Information

Health-resource use and quality of life in children with bronchiectasis: a multi-center pilot cohort study.

ABSTRACT:

Background

Bronchiectasis in children is an important, but under-researched, chronic pulmonary disorder that has negative impacts on health-related quality of life. Despite this, it does not receive the same attention as other chronic pulmonary conditions in children such as cystic fibrosis. We measured health resource use and health-related quality of life over a 12-month period in children with bronchiectasis.

Methods

We undertook a prospective cohort study of 85 children aged ResultsOverall, 951 child-months of observation were completed for 85 children (median age 8.7-years, interquartile range 5.4-11.3). The mean (standard deviation) number of exacerbations was 3.3 (2.2) per child-year. Thirty of 264 (11.4%) exacerbation episodes required hospitalization. Healthcare attendance and antibiotic use rates were high (30 and 50 per 100 child-months of observation respectively). A carer took leave from work for 53/236 (22.5%) routine clinic visits. Absences from school/childcare due to bronchiectasis were 24.9 children per 100 child-months. Quality of life scores for both the parent/carer and child were highly-correlated with one another, remained stable over time and were negatively associated with cough severity.

Conclusions

Health resource use in this cohort of children is high, reflecting their severe disease burden. Studies are now needed to quantify the direct and societal costs of disease and to evaluate interventions that may reduce disease burden, particularly hospitalizations.

SUBMITTER: Lovie-Toon YG

PROVIDER: S-EPMC6693266 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Publications

Health-resource use and quality of life in children with bronchiectasis: a multi-center pilot cohort study.

Lovie-Toon Yolanda G YG Grimwood Keith K Byrnes Catherine A CA Goyal Vikas V Busch Greta G Masters I Brent IB Marchant Julie M JM Buntain Helen H O'Grady Kerry-Ann F KF Chang Anne B AB

BMC health services research 20190813 1

<h4>Background</h4>Bronchiectasis in children is an important, but under-researched, chronic pulmonary disorder that has negative impacts on health-related quality of life. Despite this, it does not receive the same attention as other chronic pulmonary conditions in children such as cystic fibrosis. We measured health resource use and health-related quality of life over a 12-month period in children with bronchiectasis.<h4>Methods</h4>We undertook a prospective cohort study of 85 children aged < ...[more]

PMID: 31409413

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Project description:BackgroundIdentification of patient-related factors associated with Health-Related Quality of Life (HRQoL) and Quality of Life (QoL) at the start of treatment may identify patients who are prone to a decrease in HRQoL and/or QoL resulting from chemotherapy. Identification of these factors may offer opportunities to enhance patient care during treatment by adapting communication strategies and directing medical and psychological interventions. The aim was to examine the association of sociodemographic factors, personality traits, and depressive symptoms with HRQoL and QoL in patients with advanced-stage lung cancer at the start of chemotherapy.MethodsPatients (n?=?151) completed the State-Trait Anxiety Inventory (trait anxiety subscale), the Neuroticism-Extraversion-Openness-Five Factor Inventory (NEO-FFI), the Center for Epidemiologic Studies Depression (CES-D), the World Health Organization Quality of Life-BREF (WHOQOL-BREF), and the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30). Simple linear regression analyses were performed to select HRQoL and QoL associated factors (a P???0.10 was used to prevent non-identification of important factors) followed by multiple linear regression analyses (P???0.05).ResultsIn the multiple regression analyses, CES-D score (??=?-?0.63 to -?0.53; P-values <?0.001) was most often associated with the WHOQOL-BREF domains and general facet, whereas CES-D score (??=?-?0.67 to -?0.40; P-values <?0.001) and Eastern Cooperative Oncology Group (ECOG) performance status (??=?-?0.30 to -?0.30; P-values <?0.001) were most often associated with the scales of the EORTC QLQ-C30. Personality traits were not related with HRQoL or QoL except for trait anxiety (Role functioning: ??=?0.30; P?=?0.02, Environment: ??=?-?0.39; P?=?0.007) and conscientiousness (Physical health: ??=?0.20; P-value <?0.04).ConclusionsHigher scores on depressive symptoms and ECOG performance status were related to lower HRQoL and QoL in patients with advanced-stage non-small cell lung cancer. Supportive care interventions aimed at improvement of depressive symptoms and performance score may facilitate an increase of HRQoL and/or QoL during treatment.

Dataset Information

Health-resource use and quality of life in children with bronchiectasis: a multi-center pilot cohort study.

Background

Methods

Conclusions

Publications

Health-resource use and quality of life in children with bronchiectasis: a multi-center pilot cohort study.

Similar Datasets

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