Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC6693345 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Li Yumeng Y Golden Jackelyn B JB Camhi Maya I MI Zhang Xiufen X Fritz Yi Y Diaconu Doina D Ivanco Tammy L TL Simon Daniel I DI Kikly Kristine K McCormick Thomas S TS Wang Yunmei Y Ward Nicole L NL
The Journal of investigative dermatology 20170923 2
Psoriasis patients experience chronic systemic skin inflammation and develop cardiovascular comorbidities that shorten their lifespan. Whether cardiovascular disease is improved by treatment with current biologics that target disease-specific pathways is unclear. KC-Tie2 mice develop psoriasiform skin inflammation with increases in IL-23 and IL-17A and proinflammatory monocytosis and neutrophilia that precedes development of carotid artery thrombus formation. To examine whether targeted blockade ...[more]