Chronic variable stress alters hypothalamic-pituitary-adrenal axis function in the female mouse.

ABSTRACT: Chronic stress is often associated with a dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, which can greatly increase risk for a number of stress-related diseases, including neuropsychiatric disorders. Despite a striking sex-bias in the prevalence of many of these disorders, few preclinical studies have examined female subjects. Hence, the present study aimed to explore the effects of chronic stress on the basal and acute stress-induced activity of the HPA axis in the female C57BL/6 mouse. We used a chronic variable stress (CVS) paradigm in these studies, which successfully induces physiological and behavioral changes that are similar to those reported for some patients with mood disorders. Using this model, we found pronounced, time-dependent effects of chronic stress on th

SUBMITTER: Borrow AP 

PROVIDER: S-EPMC6693655 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature