Metabolic Deregulation of the Blood-Outer Retinal Barrier in Retinitis Pigmentosa.
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ABSTRACT:
SUBMITTER: Wang W
PROVIDER: S-EPMC6693665 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Publications
Metabolic Deregulation of the Blood-Outer Retinal Barrier in Retinitis Pigmentosa.
Wang Wei W Kini Ashwini A Wang Yekai Y Liu Tingting T Chen Yao Y Vukmanic Eric E Emery Douglas D Liu Yongqing Y Lu Xiaoqin X Jin Lei L Lee San Joon SJ Scott Patrick P Liu Xiao X Dean Kevin K Lu Qingxian Q Fortuny Enzo E James Robert R Kaplan Henry J HJ Du Jianhai J Dean Douglas C DC
Cell reports 20190701 5
Retinitis pigmentosa (RP) initiates with diminished rod photoreceptor function, causing peripheral and night-time vision loss. However, subsequent loss of cone function and high-resolution daylight and color vision is most debilitating. Visual pigment-rich photoreceptor outer segments (OS) undergo phagocytosis by the retinal pigment epithelium (RPE), and the RPE also acts as a blood-outer retinal barrier transporting nutrients, including glucose, to photoreceptors. We provide evidence that conta ...[more]
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