Ontology highlight
ABSTRACT:
SUBMITTER: Yin N
PROVIDER: S-EPMC6693680 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Cancer cell 20190801 2
We report that mouse LSL-Kras<sup>G12D</sup>;Trp53<sup>fl/fl</sup> (KP)-mediated lung adenocarcinoma (LADC) tumorigenesis can proceed through both PKCι-dependent and PKCι-independent pathways. The predominant pathway involves PKCι-dependent transformation of bronchoalveolar stem cells (BASCs). However, KP mice harboring conditional knock out Prkci alleles (KPI mice) develop LADC tumors through PKCι-independent transformation of Axin2<sup>+</sup> alveolar type 2 (AT2) stem cells. Transformed grow ...[more]