Dataset Information

Effects of maternal influenza vaccination on adverse birth outcomes: A systematic review and Bayesian meta-analysis.

ABSTRACT:

Background

Although pregnant women are a priority group for influenza vaccination, its effect on birth outcomes has long been debated. Numerous observational studies and a few randomized controlled studies have been conducted, with inconsistent results.

Objectives

To evaluate the association of influenza vaccination in pregnancy with adverse birth outcomes.

Data source

The Cochrane Library, PubMed, EMBASE, Web of Science, and Scopus were searched.

Study eligibility criteria

This analysis included randomized placebo-controlled studies, cohort studies, and case-control studies, in which inactivated influenza vaccination was given during pregnancy and fetal adverse birth outcomes were assessed.

Participants & intervention

Women who received inactivated influenza vaccine during pregnancy and their offspring.

Study appraisal and synthesis

Two independent reviewers and a third reviewer collaborated in study selection and data extraction. A Bayesian 3-level random-effects model was utilized to assess the impact of maternal influenza vaccination on birth outcomes, which were presented as odds ratios (ORs) with 95% credible interval (CrIs). Bayesian outcome probabilities (P) of an OR<1 were calculated, and values of at least 90% (0.9) were deemed to indicate a significant result.

Results

Among the 6,249 identified publications, 48 studies were eligible for the meta-analysis, including 2 randomized controlled trials, 41 cohort studies, and 5 case-control studies. The risk of none of the following adverse birth outcomes decreased significantly: preterm birth (OR = 0.945, 95% CrI: 0.736-1.345, P = 73.3%), low birth weight (OR = 0.928, 95% CrI: 0.432-2.112, P = 76.7%), small for gestational age (OR = 0.971, 95% CrI: 0.249-4.217,P = 63.3%), congenital malformation (OR = 1.026, 95% CrI: 0.687-1.600, P = 38.0%), and fetal death (OR = 0.942, 95% CrI: 0.560-1.954, P = 61.6%). Summary estimates including only cohort studies showed significantly decreased risks for preterm birth, small for gestational age and fetal death. However, after adjusting for season at the time of vaccination and countries' income level, only fetal death remained significant.

Conclusion

This Bayesian meta-analysis did not find a protective effect of maternal influenza vaccination against adverse birth outcomes, as reported in previous studies. In fact, our results showed evidence of null associations between maternal influenza vaccination and adverse birth outcomes.

SUBMITTER: Jeong S

PROVIDER: S-EPMC6693758 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Effects of maternal influenza vaccination on adverse birth outcomes: A systematic review and Bayesian meta-analysis.

Jeong Sohyun S Jang Eun Jin EJ Jo Junwoo J Jang Sunmee S

PloS one 20190814 8

<h4>Background</h4>Although pregnant women are a priority group for influenza vaccination, its effect on birth outcomes has long been debated. Numerous observational studies and a few randomized controlled studies have been conducted, with inconsistent results.<h4>Objectives</h4>To evaluate the association of influenza vaccination in pregnancy with adverse birth outcomes.<h4>Data source</h4>The Cochrane Library, PubMed, EMBASE, Web of Science, and Scopus were searched.<h4>Study eligibility crite ...[more]

PMID: 31412058

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Dataset Information

Effects of maternal influenza vaccination on adverse birth outcomes: A systematic review and Bayesian meta-analysis.

Background

Objectives

Data source

Study eligibility criteria

Participants & intervention

Study appraisal and synthesis

Results

Conclusion

Publications

Effects of maternal influenza vaccination on adverse birth outcomes: A systematic review and Bayesian meta-analysis.

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