Fatty acid synthase downregulation contributes to acute lung injury in murine diet-induced obesity.
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ABSTRACT:
SUBMITTER: Plataki M
PROVIDER: S-EPMC6693837 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
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Fatty acid synthase downregulation contributes to acute lung injury in murine diet-induced obesity.
Plataki Maria M Fan LiChao L Sanchez Elizabeth E Huang Ziling Z Torres Lisa K LK Imamura Mitsuru M Zhu Yizhang Y Cohen David E DE Cloonan Suzanne M SM Choi Augustine Mk AM
JCI insight 20190709
The prevalence of obesity is rising worldwide and obese patients comprise a specific population in the intensive care unit. Acute respiratory distress syndrome (ARDS) incidence is increased in obese patients. Exposure of rodents to hyperoxia mimics many of the features of ARDS. In this report, we demonstrate that high fat diet induced obesity increases the severity of hyperoxic acute lung injury in mice in part by altering fatty acid synthase (FASN) levels in the lung. Obese mice exposed to hype ...[more]
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