Ontology highlight
ABSTRACT:
SUBMITTER: New AM
PROVIDER: S-EPMC6694120 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Nature communications 20190814 1
We lack an understanding of how the full range of genetic variants that occur in individuals can interact. To address this shortcoming, here we combine diverse mutations between genes in a model regulatory network, the galactose (GAL) switch of budding yeast. The effects of thousands of pairs of mutations fall into a limited number of phenotypic classes. While these effects are mostly predictable using simple rules that capture the 'stereotypical' genetic interactions of the network, some double ...[more]