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Synthesis of MgAC-Fe3O4/TiO2 hybrid nanocomposites via sol-gel chemistry for water treatment by photo-Fenton and photocatalytic reactions.

ABSTRACT: MgAC-Fe3O4/TiO2 hybrid nanocomposites were synthesized in different ratios of MgAC-Fe3O4 and TiO2 precursor. X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray fluorescence spectrometry (XRF), electron spin resonance spectrometry (ESR), Brunauer-Emmett-Teller (BET), photoluminescence (PL), and UV photoelectron spectroscopy (UPS) were used to characterize the nanocomposites. The increase of MgAC-Fe3O4, in the hybrid nanocomposites' core-shell structure, led to the decrease of anatase TiO2 peaks, thus reducing the photo-Fenton and photocatalytic activities. According to the obtained data, MgAC-Fe3O4 [0.05?g]/TiO2 showed the best photo-Fenton and photocatalytic activities, having removed ~93% of MB (photo-Fenton reaction) and ~80% of phenol (photocatalytic reaction) after 20 and 80?mins, respectively. On the pilot scale (30?L), MgAC-Fe3O4 [0.05?g]/TiO2 was completely removed after 27 and 30?hours by the photo-Fenton and photocatalytic activities, respectively. The synergistic effect gained from the combined photo-Fenton and photocatalytic activities of Fe3O4 and TiO2, respectively, was credited for the performances of the MgAC-Fe3O4/TiO2 hybrid nanocomposites.

SUBMITTER: Bui VKH

PROVIDER: S-EPMC6694146 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Synthesis of MgAC-Fe3O4/TiO2 hybrid nanocomposites via sol-gel chemistry for water treatment by photo-Fenton and photocatalytic reactions.

Bui Vu Khac Hoang VKH Park Duckshin D Pham Tuyet Nhung TN An Yejin Y Choi Jin Seok JS Lee Hyun Uk HU Kwon Oh-Hyeok OH Moon Ju-Young JY Kim Ki-Tae KT Lee Young-Chul YC

Scientific reports 20190814 1

MgAC-Fe3O4/TiO2 hybrid nanocomposites were synthesized in different ratios of MgAC-Fe3O4 and TiO2 precursor. X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray fluorescence spectrometry (XRF), electron spin resonance spectrometry (ESR), Brunauer-Emmett-Teller (BET), photoluminescence (PL), and UV photoelectron spectroscopy (UPS) were used to characterize the nanocomposites. T ...[more]

PMID: 31413304

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Project description:BackgroundNeuroblastoma is the most common extracranial solid malignancy in childhood which, despite the current progress in radiotherapy and chemotherapy protocols, still has a high mortality rate in high risk tumors. Nanomedicine offers exciting and unexploited opportunities to overcome the shortcomings of conventional medicine. The photocatalytic properties of Fe3O4 core-TiO2 shell nanocomposites and their potential for cell specific targeting suggest that nanoconstructs produced using Fe3O4 core-TiO2 shell nanocomposites could be used to enhance radiation effects in neuroblastoma. In this study, we evaluated bare, metaiodobenzylguanidine (MIBG) and 3,4-Dihydroxyphenylacetic acid (DOPAC) coated Fe3O4@TiO2 as potential radiosensitizers for neuroblastoma in vitro.ResultsThe uptake of bare and MIBG coated nanocomposites modestly sensitized neuroblastoma cells to ionizing radiation. Conversely, cells exposed to DOPAC coated nanocomposites exhibited a five-fold enhanced sensitivity to radiation, increased numbers of radiation induced DNA double-strand breaks, and apoptotic cell death. The addition of a peptide mimic of the epidermal growth factor (EGF) to nanoconjugates coated with MIBG altered their intracellular distribution. Cryo X-ray fluorescence microscopy tomography of frozen hydrated cells treated with these nanoconjugates revealed cytoplasmic as well as nuclear distribution of the nanoconstructs.ConclusionsThe intracellular distribution pattern of different nanoconjugates used in this study was different for different nanoconjugate surface molecules. Cells exposed to DOPAC covered nanoconjugates showed the smallest nanoconjugate uptake, with the most prominent pattern of large intracellular aggregates. Interestingly, cells treated with this nanoconjugate also showed the most pronounced radiosensitization effect in combination with the external beam x-ray irradiation. Further studies are necessary to evaluate mechanistic basis for this increased radiosensitization effect. Preliminary studies with the nanoparticles carrying an EGF mimicking peptide showed that this approach to targeting could perhaps be combined with a different approach to radiosensitization - use of nanoconjugates in combination with the radioactive iodine. Much additional work will be necessary in order to evaluate possible benefits of targeted nanoconjugates carrying radionuclides.Graphic abstractSupplementary informationThe online version contains supplementary material available at 10.1186/s12645-021-00081-z.

Dataset Information

Synthesis of MgAC-Fe3O4/TiO2 hybrid nanocomposites via sol-gel chemistry for water treatment by photo-Fenton and photocatalytic reactions.

Publications

Synthesis of MgAC-Fe<sub>3</sub>O<sub>4</sub>/TiO<sub>2</sub> hybrid nanocomposites via sol-gel chemistry for water treatment by photo-Fenton and photocatalytic reactions.

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