Ontology highlight
ABSTRACT:
SUBMITTER: Rivosecchi J
PROVIDER: S-EPMC6694214 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Rivosecchi Julieta J Larochelle Marc M Teste Camille C Grenier Frédéric F Malapert Amélie A Ricci Emiliano P EP Bernard Pascal P Bachand François F Vanoosthuyse Vincent V
The EMBO journal 20190711 16
R-loop disassembly by the human helicase Senataxin contributes to genome integrity and to proper transcription termination at a subset of RNA polymerase II genes. Whether Senataxin also contributes to transcription termination at other classes of genes has remained unclear. Here, we show that Sen1, one of two fission yeast homologues of Senataxin, promotes efficient termination of RNA polymerase III (RNAP3) transcription in vivo. In the absence of Sen1, RNAP3 accumulates downstream of RNAP3-tran ...[more]