Changes in visual function and retinal structure in the progression of Alzheimer's disease.

ABSTRACT:

Background

Alzheimer's Disease (AD) can cause degeneration in the retina and optic nerve either directly, as a result of amyloid beta deposits, or secondarily, as a result of the degradation of the visual cortex. These effects raise the possibility that tracking ophthalmologic changes in the retina can be used to assess neurodegeneration in AD. This study aimed to detect retinal changes and associated functional changes in three groups of patients consisting of AD patients with mild disease, AD patients with moderate disease and healthy controls by using non-invasive psychophysical ophthalmological tests and optical coherence tomography (OCT).

Methods

We included 39 patients with mild AD, 21 patients with moderate AD and 40 age-matched healthy controls. Both patients and con

SUBMITTER: Salobrar-Garcia E 

PROVIDER: S-EPMC6695171 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature