Eye-of-the-tiger Sign in Neurodegeneration with Brain Iron Accumulation.

ABSTRACT: A 68-year-old male patient presented to the neurology clinic with tremor, lightheadedness, and a history of syncope. Exam showed mild Parkinsonism. Neuroimaging revealed symmetric lesions of the globus pallidus (the eye-of-the-tiger sign) concerning for neurodegeneration with brain iron accumulation (NBIA). Genetic panel for NBIA was ordered, specifically pantothenate kinase-associated neurodegeneration (PKAN), including pantothenate kinase 2 (PanK2) - the genetic marker for the pantothenate kinase enzyme.

SUBMITTER: Goldberg M 

PROVIDER: S-EPMC6695239 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature