Role of Screening History in Clinical Meaning and Optimal Management of Positive Cervical Screening Results.

ABSTRACT: BACKGROUND:Cervical cancer is caused by persistent human papillomavirus (HPV) infection. US consensus management guidelines for a positive cervical screening result typically focus on the current screening result only. A negative testing history may alter risk of the following positive screening results, caused by a new HPV infection, and therefore its optimal management. METHODS:Women ages 30 years and older were screened with triennial HPV and cytology co-testing at Kaiser Permanente Northern California from 2003 to 2014. We estimated the subsequent 5-year risks of cervical intraepithelial neoplasia grade 3 or more severe diagnoses (CIN3+) in a cohort of 1 156 387 women following abnormal (atypical squamous cells of undetermined significance [ASC-US] or worse) cytology and/or positive HP

SUBMITTER: Castle PE 

PROVIDER: S-EPMC6695308 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature