Ontology highlight
ABSTRACT:
SUBMITTER: Gray V
PROVIDER: S-EPMC6695319 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Gray Victoria V Briggs Sarah S Palles Claire C Jaeger Emma E Iveson Timothy T Kerr Rachel R Saunders Mark P MP Paul James J Harkin Andrea A McQueen John J Summers Matthew G MG Johnstone Elaine E Wang Haitao H Gatcombe Laura L Maughan Timothy S TS Kaplan Richard R Escott-Price Valentina V Al-Tassan Nada A NA Meyer Brian F BF Wakil Salma M SM Houlston Richard S RS Cheadle Jeremy P JP Tomlinson Ian I Church David N DN
Journal of the National Cancer Institute 20190801 8
<h4>Background</h4>Constitutional loss of function (LOF) single nucleotide polymorphisms (SNPs) in pattern recognition receptors FPR1, TLR3, and TLR4 have previously been reported to predict oxaliplatin benefit in colorectal cancer. Confirmation of this association could substantially improve patient stratification.<h4>Methods</h4>We performed a retrospective biomarker analysis of the Short Course in Oncology Therapy (SCOT) and COIN/COIN-B trials. Participant status for LOF variants in FPR1 (rs8 ...[more]