Ontology highlight
ABSTRACT:
SUBMITTER: Rozbesky D
PROVIDER: S-EPMC6695400 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Rozbesky Daniel D Robinson Ross A RA Jain Vitul V Renner Max M Malinauskas Tomas T Harlos Karl K Siebold Christian C Jones E Yvonne EY
Nature communications 20190815 1
Semaphorin ligands and their plexin receptors are one of the major cell guidance factors that trigger localised changes in the cytoskeleton. Binding of semaphorin homodimer to plexin brings two plexins in close proximity which is a prerequisite for plexin signalling. This model appears to be too simplistic to explain the complexity and functional versatility of these molecules. Here, we determine crystal structures for all members of Drosophila class 1 and 2 semaphorins. Unlike previously report ...[more]