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Relationship between ocular biometry and severity of primary angle-closure glaucoma: relevance for predictive, preventive, and personalized medicine.


ABSTRACT: Background:Several ocular factors have been identified for primary angle-closure glaucoma (PACG), such as a small cornea, elevated intraocular pressure (IOP), shallow anterior chamber, and short axial length (AL). However, the relationship between the severity of PACG and various ocular parameters [IOP, anterior chamber depth, AL, central corneal thickness] is not fully understood. Methods:A 7-year cross-sectional study. A total of 2254 eyes of 1312 PACG patients (females?=?856 [1479 eyes] and males?=?456 [775 eyes]) were included. A detailed eye examination was performed. The participants were categorized into gender subgroups followed by subdivision into three different severity groups according to their mean deviation (MD) of the visual fields results as follows: mild (MD ??6 dB), moderate (MD 6-12 dB), and severe (MD >?12 dB) PACG. The associations of ocular biometry with severity of PACG were analyzed using paired Student's t test, multivariate linear regression, and logistic regression analysis. Results:There was a significant positive correlation between the MD and AL in the female subgroup (B?=?0.663, p?=?0.001, 95%CI?=?1.070 to 1.255) but not in the male subgroup. Increased AL levels (mild [OR?=?1], moderate [OR?=?1.047, p?=?0.062, 95%CI?=?0.947 to 2.462], and severe [OR?=?1.274, p?

SUBMITTER: Li S 

PROVIDER: S-EPMC6695461 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Relationship between ocular biometry and severity of primary angle-closure glaucoma: relevance for predictive, preventive, and personalized medicine.

Li Shengjie S   Shao Mingxi M   Wan Yani Y   Tang Binghua B   Sun Xinghuai X   Cao Wenjun W  

The EPMA journal 20190611 3


<h4>Background</h4>Several ocular factors have been identified for primary angle-closure glaucoma (PACG), such as a small cornea, elevated intraocular pressure (IOP), shallow anterior chamber, and short axial length (AL). However, the relationship between the severity of PACG and various ocular parameters [IOP, anterior chamber depth, AL, central corneal thickness] is not fully understood.<h4>Methods</h4>A 7-year cross-sectional study. A total of 2254 eyes of 1312 PACG patients (females = 856 [1  ...[more]

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