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Predictive value and clinical significance of increased SSAT-1 activity in healthy adults.

ABSTRACT: Aim:Spermidine/spermine N1-acetyltransferase (SSAT-1) regulates cell growth, proliferation and death. Amantadine is converted by SSAT-1 to acetylamantadine (AA). In our earlier studies, although SSAT-1 was activated in patients with cancer, a number of ostensibly healthy adult volunteers had higher than expected AA concentration. This study was therefore undertaken to examine the outlier group. Materials & methods:A follow up of urine analysis for AA by liquid chromatography-tandem mass spectrometry as well as clinical assessments and additional blood analyses were conducted. Results:In some of the outlier controls, higher than expected AA concentration was linked to increased serum carcinoembryonic antigen. Clinical and radiographic assessments revealed underlying abnormalities in other cases that could represent premalignant conditions. Hematology tests revealed elevations in white blood cells and platelets, which are markers of inflammation. Conclusion:High urine concentration of AA could be used as a simple and useful test for screening of cancer in high-risk populations.

SUBMITTER: Tappia PS

PROVIDER: S-EPMC6695528 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Predictive value and clinical significance of increased SSAT-1 activity in healthy adults.

Tappia Paramjit S PS Maksymiuk Andrew W AW Sitar Daniel S DS Akhtar Parveen S PS Khatun Nazrina N Parveen Rahnuma R Ahmed Rashiduzzaman R Ahmed Rashid B RB Cheng Brian B Huang Gina G Bach Horacio H Hiebert Brett B Ramjiawan Bram B

Future science OA 20190701 7

<h4>Aim</h4>Spermidine/spermine N<sup>1</sup>-acetyltransferase (SSAT-1) regulates cell growth, proliferation and death. Amantadine is converted by SSAT-1 to acetylamantadine (AA). In our earlier studies, although SSAT-1 was activated in patients with cancer, a number of ostensibly healthy adult volunteers had higher than expected AA concentration. This study was therefore undertaken to examine the outlier group.<h4>Materials & methods</h4>A follow up of urine analysis for AA by liquid chromatog ...[more]

PMID: 31428447

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Predictive value and clinical significance of increased SSAT-1 activity in healthy adults.

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Predictive value and clinical significance of increased SSAT-1 activity in healthy adults.

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