Toxicokinetic Study of a Gastroprotective Dose of Capsaicin by HPLC-FLD Method.

ABSTRACT: A low dose of capsaicin and its natural homologs and analogs (capsaicinoids) have shown to prevent development of gastric mucosal damage of alcohol and non-steroid anti-inflammatory drugs. Based on this experimental observation, a drug development program has been initiated to develop per os applicable capsaicin containing drugs to eliminate gastrointestinal damage caused by non-steroid anti-inflammatory drugs. As a part of this program, a sensitive and selective reverse-phase high-performance liquid chromatography-based method with fluorescence detection has been developed for quantification of capsaicin and dihydrocapsaicin in experimental dog's plasma. The method was evaluated for a number of validation characteristics (selectivity, repeatability, and intermediate precision, LOD, LOQ, a

SUBMITTER: Kuzma M 

PROVIDER: S-EPMC6695877 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature