The Role of Prep1 in the Regulation of Mesenchymal Stromal Cells.
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ABSTRACT:
SUBMITTER: Maroni G
PROVIDER: S-EPMC6696203 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Publications
The Role of Prep1 in the Regulation of Mesenchymal Stromal Cells.
Maroni Giorgia G Panetta Daniele D Luongo Raffaele R Krishnan Indira I La Rosa Federica F Campani Daniela D Salvadori Piero P Iozzo Patricia P Blasi Francesco F Penkov Dmitry D Levantini Elena E Magli Maria Cristina MC
International journal of molecular sciences 20190725 15
Molecular mechanisms governing cell fate decision events in bone marrow mesenchymal stromal cells (MSC) are still poorly understood. Herein, we investigated the homeobox gene <i>Prep1</i> as a candidate regulatory molecule, by adopting <i>Prep1</i> hypomorphic mice as a model to investigate the effects of <i>Prep1</i> downregulation, using in vitro and in vivo assays, including the innovative single cell RNA sequencing technology. Taken together, our findings indicate that low levels of <i>Prep1 ...[more]
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