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The Human Coronary Collateral Circulation, Its Extracardiac Anastomoses and Their Therapeutic Promotion.


ABSTRACT: Cardiovascular disease remains the leading global cause of death, and the number of patients with coronary artery disease (CAD) and exhausted therapeutic options (i.e., percutaneous coronary intervention (PCI), coronary artery bypass grafting (CABG) and medical treatment) is on the rise. Therefore, the evaluation of new therapeutic approaches to offer an alternative treatment strategy for these patients is necessary. A promising research field is the promotion of the coronary collateral circulation, an arterio-arterial network able to prevent or reduce myocardial ischemia in CAD. This review summarizes the basic principles of the human coronary collateral circulation, its extracardiac anastomoses as well as the different therapeutic approaches, especially that of stimulating the extracardiac collateral circulation via permanent occlusion of the internal mammary arteries.

SUBMITTER: Bigler MR 

PROVIDER: S-EPMC6696371 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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The Human Coronary Collateral Circulation, Its Extracardiac Anastomoses and Their Therapeutic Promotion.

Bigler Marius Reto MR   Seiler Christian C  

International journal of molecular sciences 20190730 15


Cardiovascular disease remains the leading global cause of death, and the number of patients with coronary artery disease (CAD) and exhausted therapeutic options (i.e., percutaneous coronary intervention (PCI), coronary artery bypass grafting (CABG) and medical treatment) is on the rise. Therefore, the evaluation of new therapeutic approaches to offer an alternative treatment strategy for these patients is necessary. A promising research field is the promotion of the coronary collateral circulat  ...[more]

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