Effects of Aging on Hair Color, Melanosome Morphology, and Melanin Composition in Japanese Females.

ABSTRACT: In a previous study, we showed that the size of melanosomes isolated from Japanese female hairs enlarges with age, and this affects the hair color. In this study, we analyzed the age-dependent changes in hair melanin in order to further explore the factors related to hair color changing by aging. A significant positive correlation with age was found in the total melanin amount (TM) and the mol% of 5,6-dihydroxyindole (DHI) units, while no correlation was found in pheomelanin mol%. TM showed significant correlations with hair color parameters and the melanosome volume, suggesting that hair color darkening by aging is caused by the increase in TM due to the enlargement of the size of melanosome. From the measurement of absorbance spectra on synthetic eumelanins with different ratios of DHI a

SUBMITTER: Itou T 

PROVIDER: S-EPMC6696507 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature