Ontology highlight
ABSTRACT:
SUBMITTER: Ligorio M
PROVIDER: S-EPMC6697165 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Ligorio Matteo M Sil Srinjoy S Malagon-Lopez Jose J Nieman Linda T LT Misale Sandra S Di Pilato Mauro M Ebright Richard Y RY Karabacak Murat N MN Kulkarni Anupriya S AS Liu Ann A Vincent Jordan Nicole N Franses Joseph W JW Philipp Julia J Kreuzer Johannes J Desai Niyati N Arora Kshitij S KS Rajurkar Mihir M Horwitz Elad E Neyaz Azfar A Tai Eric E Magnus Neelima K C NKC Vo Kevin D KD Yashaswini Chittampalli N CN Marangoni Francesco F Boukhali Myriam M Fatherree Jackson P JP Damon Leah J LJ Xega Kristina K Desai Rushil R Choz Melissa M Bersani Francesca F Langenbucher Adam A Thapar Vishal V Morris Robert R Wellner Ulrich F UF Schilling Oliver O Lawrence Michael S MS Liss Andrew S AS Rivera Miguel N MN Deshpande Vikram V Benes Cyril H CH Maheswaran Shyamala S Haber Daniel A DA Fernandez-Del-Castillo Carlos C Ferrone Cristina R CR Haas Wilhelm W Aryee Martin J MJ Ting David T DT
Cell 20190530 1
Single-cell technologies have described heterogeneity across tissues, but the spatial distribution and forces that drive single-cell phenotypes have not been well defined. Combining single-cell RNA and protein analytics in studying the role of stromal cancer-associated fibroblasts (CAFs) in modulating heterogeneity in pancreatic cancer (pancreatic ductal adenocarcinoma [PDAC]) model systems, we have identified significant single-cell population shifts toward invasive epithelial-to-mesenchymal tr ...[more]