Ontology highlight
ABSTRACT:
SUBMITTER: Wu X
PROVIDER: S-EPMC6697347 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Wu Xiuqi X Luo Hong H Shi Bizhi B Di Shengmeng S Sun Ruixin R Su Jingwen J Liu Ying Y Li Hua H Jiang Hua H Li Zonghai Z
Molecular therapy : the journal of the American Society of Gene Therapy 20190429 8
Our previous study indicated that GPC3-targeted chimeric antigen receptor (CAR) T cell therapy has a high safety profile in patients with hepatocellular carcinoma (HCC). However, the response rate requires further improvement. Here, we analyzed the combined effect of GPC3-CAR T cells and sorafenib in both immunocompetent and immunodeficient mouse models of hepatocellular carcinoma. In immunocompetent mouse model, mouse CAR (mCAR) T cells induced regression of small tumors (approximately 130 mm<s ...[more]